Sabrina Mattoli, M.D., Ph.D.

 

 

 

Selected  Publications

 

Mattoli S. Pathogenetic and prognostic role of bloodborne fibrocytes in asthma. Invited Review. J Zhejiang Univ Sci B. 2015; 16(8): 651-660. http://dx.doi.org/10.1631/Jzus.B1500129. PubMed PMID: 26238540.

 

Barczyk M, Schmidt M, Mattoli S. Stem cell-based therapy in idiopathic pulmonary fibrosis. Stem Cell Rev. 2015; 11(4): 598-620. Epub ahead of print 21 Apr 2015. http://dx.doi.org/10.1007/s12015-015-9587-7. PubMed PMID: 25896401.

 

Mattoli S. Involvement of fibrocytes in asthma and clinical implications. Invited Review. Clin Exp Allergy. 2015; 45: 1497-1509. Epub ahead of print 5 Mar 2015. http://dx.doi.org/10.1111/cea.12525. PubMed PMID: 25752439.

 

Bianchetti L, Isgrò M, Marini MA, Bellini A, Schmidt M, Mattoli S. Enumeration of circulating fibrocytes for clinical use in asthma by an optimized single-platform flow cytometry assay. BBA Clin. 2014; 1: 52-58. http://dx.doi.org/10.1016/j.bbacli.2014.06.002. eCollection 2014 Jun. PubMed PMID: 26673636.

 

Schmidt M, Mattoli S. A mouse model for evaluating the contribution of fibrocytes and myofibroblasts to airway remodeling in allergic asthma. In: Mouse Models of Allergic Disease: Methods and Protocols. Chapter 19. Allen IC, Ed. Methods Mol Biol. 2013; 1032: 235-255http://dx.doi.org/10.1007/978-1-62703-496-8_19. PubMed PMID: 23943458.

 

Isgrò M, Bianchetti L, Marini MA, Mattoli S. Involvement of fibrocytes in allergen-induced T cell responses and rhinovirus infections in asthma. Biochem Biophys Res Commun. 2013 August 2; 437(3): 446-451. Epub 2013, July 3. http://dx.doi.org/10.1016/j.bbrc.2013.06.099. PubMed PMID: 2383127.

 

Bellini A, Schmidt M, Mattoli S. Interactions between the bronchial epithelium and fibrocytes in the pathogenesis of airway remodeling in asthma. Journal of Epithelial Biology and Pharmacology 2013; 6: 1-10. http://dx.doi.org/10.2174/1875044301306010001.

 

Isgrò M, Bianchetti L, Marini MA, Bellini A, Schmidt M, Mattoli S. The C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthma. Mucosal Immunol. 2013 July; 6(4): 718-727. Epub 2012, Nov 14. http://dx.doi.org/10.1038/mi.2012.109. PubMed PMID: 23149666.

 

Bianchetti L, Marini MA, Isgrò M, Bellini A, Schmidt M, Mattoli S. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. Biochem Biophys Res Commun. 2012 Sep 14;426(1):116-21. http://dx.doi.org/10.1016/j.bbrc.2012.08.047. Epub 2012 Aug 17. PubMed PMID: 22921786.

 

Mattoli S, Barczyk M, Bellini A. Fibrocytes in Asthma. In: Fibrocytes in Health and Disease. Chapter 7. Bucala R, Ed. Singapore: World Scientific Publishing. 2012: 113-30.

 

Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012 Mar;5(2):140-9. http://dx.doi.org/10.1038/mi.2011.60. Epub 2011 Dec 21. PubMed PMID: 22189956.

 

Bianchetti L, Barczyk M, Cardoso J, Schmidt M, Bellini A, Mattoli S. Extracellular matrix remodelling properties of human fibrocytes. J Cell Mol Med. 2012 Mar;16(3):483-95. http://dx.doi.org/10.1111/j.1582-4934.2011.01344.x. PubMed PMID: 21595824.

 

Bellini A, Mattoli S. Fibrocytes (Reactive or Reparative). In: Cell Therapy for Lung Disease. Chapter 8. Polak J, Ed. London: Imperial College Press. 2010: 237-52.

 

Mattoli S, Bellini A, Schmidt M. The role of a human hematopoietic mesenchymal progenitor in wound healing and fibrotic diseases and implications for therapy. Curr Stem Cell Res Ther. 2009 Dec;4(4):266-80. Review. http://dx.doi.org/10.2174/157488809789649232. PubMed PMID: 19500063.

 

Schmidt M, Mattoli S. Role in asthmatic lung disease. In: Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Chapter 6. Bucala R, Ed. Singapore: World Scientific Publishing. 2007:105-23.

 

Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest. 2007 Sep;87(9):858-70. Epub 2007 Jul 2. Review. PubMed PMID: 17607298.

 

Mattoli S. Tissue repair in asthma: The origin of subepithelial fibroblasts and myofibroblasts. In: Tissue Repair, Contraction and the Myofibroblasts. Chapter 4. Chaponnier C, Desmoulière A, Gabbiani G, Eds. Georgetown (TX): Landes Bioscience and Springer Science + Business Media. 2006:40-6

 

Mori L, Bellini A, Stacey MA, Schmidt M, Mattoli S. Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp Cell Res. 2005 Mar 10;304(1):81-90. Epub 2004 Dec 8. PubMed PMID: 15707576.

 

Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003 Jul 1;171(1):380-9. PubMed PMID: 12817021.

 

Mattoli S. Allergen-induced generation of mediators in the mucosa. Environ Health Perspect. 2001 Aug;109 Suppl 4:553-7. Review. PubMed PMID: 11544162; PubMed Central PMCID: PMC1240580.

 

Sun G, Stacey MA, Schmidt M, Mori L, Mattoli S. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol. 2001 Jul 15;167(2):1014-21. PubMed PMID: 11441110.

 

Brown JR, Kleimberg J, Marini M, Sun G, Bellini A, Mattoli S. Kinetics of eotaxin expression and its relationship to eosinophil accumulation and activation in bronchial biopsies and bronchoalveolar lavage (BAL) of asthmatic patients after allergen inhalation. Clin Exp Immunol. 1998 Nov;114(2):137-46. PubMed PMID: 9822268; PubMed Central PMCID: PMC1905105.

 

Sun G, Stacey MA, Vittori E, Marini M, Bellini A, Kleimberg J, Mattoli S. Cellular and molecular  characteristics of inflammation in chronic bronchitis. Eur J Clin Invest. 1998 May;28(5):364-72. PubMed PMID: 9650009.

 

Mattoli S, Kleimberg J, Stacey MA, Bellini A, Sun G, Marini M. The role of CD8+ Th2 lymphocytes in the development of smoking-related lung damage. Biochem Biophys Res Commun. 1997 Oct 9;239(1):146-9. PubMed PMID: 9345285.

 

Stacey MA, Sun G, Vassalli G, Marini M, Bellini A, Mattoli S. The allergen Der p1 induces NF-kappaB activation through interference with IkappaB alpha function in asthmatic bronchial epithelial cells. Biochem Biophys Res Commun. 1997 Jul 18;236(2):522-6. PubMed PMID: 9240473.

 

Mattoli S, Stacey MA, Sun G, Bellini A, Marini M. Eotaxin expression and eosinophilic inflammation in asthma. Biochem Biophys Res Commun. 1997 Jul 18;236(2):299-301. PubMed PMID: 9240429.

 

Sun G, Stacey MA, Bellini A, Marini M, Mattoli S. Endothelin-1 induces bronchial myofibroblast differentiation. Peptides. 1997;18(9):1449-51. PubMed PMID: 9392850.

 

Sun G, De Angelis G, Nucci F, Ackerman V, Bellini A, Mattoli S. Functional analysis of the preproendothelin-1 gene promoter in pulmonary epithelial cells and monocytes. Biochem Biophys Res Commun. 1996 Apr 25;221(3):647-52. PubMed PMID: 8630015.

 

Marini M, Carpi S, Bellini A, Patalano F, Mattoli S. Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells. Biochem Biophys Res Commun. 1996 Mar 27;220(3):896-9. PubMed PMID: 8607863.

 

Manni A, Kleimberg J, Ackerman V, Bellini A, Patalano F, Mattoli S. Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity. Biochem Biophys Res Commun. 1996 Mar 7;220(1):120-4. PubMed PMID: 8602829.

 

Mori L, Kleimberg J, Mancini C, Bellini A, Marini M, Mattoli S. Bronchial epithelial cells of atopic patients with asthma lack the ability to inactivate allergens. Biochem Biophys Res Commun. 1995 Dec 26;217(3):817-24. PubMed PMID: 8554603.

 

Ackerman V, Carpi S, Bellini A, Vassalli G, Marini M, Mattoli S. Constitutive expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by histamine and interleukin-1. J Allergy Clin Immunol. 1995 Nov;96(5 Pt 1):618-27. PubMed PMID: 7499678.

 

Gibson PG, Mattoli S, Sears MR, Dolovich J, Hargreave FE. Increased peak flow variability in children with asymptomatic hyperresponsiveness. Eur Respir J. 1995 Oct;8(10):1731-5. PubMed PMID: 8586130.

 

Mattoli S, Ackerman V, Vittori E, Marini M. Mast cell chemotactic activity of RANTES. Biochem Biophys Res Commun. 1995 Apr 6;209(1):316-21. PubMed PMID: 7537040.

 

Ackerman V, Marini M, Vittori E, Bellini A, Vassali G, Mattoli S. Detection of cytokines and their cell sources in bronchial biopsy specimens from asthmatic patients. Relationship to atopic status, symptoms, and level of airway hyperresponsiveness. Chest. 1994 Mar;105(3):687-96. PubMed PMID: 8131526.

 

Carpi S, Marini M, Vittori E, Vassalli G, Mattoli S. Bronchoconstrictive responses to inhaled ultrasonically nebulized distilled water and airway inflammation in asthma. Chest. 1993 Nov;104(5):1346-51. PubMed PMID: 8222786.

 

Bellini A, Yoshimura H, Vittori E, Marini M, Mattoli S. Bronchial epithelial cells of patients with asthma release chemoattractant factors for T lymphocytes. J Allergy Clin Immunol. 1993 Sep;92(3):412-24. PubMed PMID: 8360392.

 

Bellini A, Vittori E, Marini M, Ackerman V, Mattoli S. Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma. Chest. 1993 Apr;103(4):997-1005. PubMed PMID: 8131514.

 

Vittori E, Marini M, Fasoli A, De Franchis R, Mattoli S. Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effect of corticosteroids. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1320-5. PubMed PMID: 1443891.

 

Marini M, Avoni E, Hollemborg J, Mattoli S. Cytokine mRNA profile and cell activation in bronchoalveolar lavage fluid from nonatopic patients with symptomatic asthma. Chest. 1992 Sep;102(3):661-9. PubMed PMID: 1516385.

 

Vittori E, Sciacca F, Colotta F, Mantovani A, Mattoli S. Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells. J Allergy Clin Immunol. 1992 Jul;90(1):76-84. PubMed PMID: 1321178.

 

Marini M, Vittori E, Hollemborg J, Mattoli S. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol. 1992 May;89(5):1001-9. PubMed PMID: 1583242.

 

Mattoli S, Marini M, Fasoli A. Expression of the potent inflammatory cytokines, GM-CSF, IL6, and IL8, in bronchial epithelial cells of asthmatic patients. Chest. 1992 Mar;101(3 Suppl):27S-29S. PubMed PMID: 1311668.

 

Marini M, Soloperto M, Zheng Y, Mezzetti M, Mattoli S. Protective effect of nedocromil sodium on the IL1-induced release of GM-CSF from cultured human bronchial epithelial cells. Pulm Pharmacol. 1992;5(1):61-5. PubMed PMID: 1317231.

 

Mattoli S, Colotta F, Fincato G, Mezzetti M, Mantovani A, Patalano F, Fasoli A. Time course of IL1 and IL6 synthesis and release in human bronchial epithelial cell cultures exposed to toluene diisocyanate. J Cell Physiol. 1991 Nov;149(2):260-8. PubMed PMID: 1660901.

 

Mattoli S, Soloperto M, Mezzetti M, Fasoli A. Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin 1. Am J Respir Cell Mol Biol. 1991 Nov;5(5):424-30. PubMed PMID: 1657061.

 

Mattoli S, Soloperto M, Marini M, Fasoli A. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J Allergy Clin Immunol. 1991 Sep;88(3 Pt 1):376-84. PubMed PMID: 1890266.

 

Marini M, Soloperto M, Mezzetti M, Fasoli A, Mattoli S. Interleukin-1 binds to specific receptors on human bronchial epithelial cells and upregulates granulocyte/macrophage colony-stimulating factor synthesis and release. Am J Respir Cell Mol Biol. 1991 Jun;4(6):519-24. PubMed PMID: 1828952.

 

Soloperto M, Mattoso VL, Fasoli A, Mattoli S. A bronchial epithelial cell-derived factor in asthma that promotes eosinophil activation and survival as GM-CSF. Am J Physiol. 1991 Jun;260(6 Pt 1):L530-8. PubMed PMID: 1647680.

 

Mezzetti M, Soloperto M, Fasoli A, Mattoli S. Human bronchial epithelial cells modulate CD3 and mitogen-induced DNA synthesis in T cells but function poorly as antigen-presenting cells compared to pulmonary macrophages. J Allergy Clin Immunol. 1991 May;87(5):930-8. PubMed PMID: 1827479.

 

Mattoli S, Mattoso VL, Soloperto M, Allegra L, Fasoli A. Cellular and biochemical characteristics of bronchoalveolar lavage fluid in symptomatic nonallergic asthma. J Allergy Clin Immunol. 1991 Apr;87(4):794-802. PubMed PMID: 2013675.

 

Soloperto M, Marini M, Brasca C, Fasoli A, Mattoli S. The protective effect of frusemide on the generation of superoxide anions by human bronchial epithelial cells and pulmonary macrophages in vitro. Pulm Pharmacol. 1991;4(2):80-4. PubMed PMID: 1666531.

 

Mattoli S, Miante S, Calabrò F, Mezzetti M, Fasoli A, Allegra L. Bronchial epithelial cells exposed to isocyanates potentiate activation and proliferation of T-cells. Am J Physiol. 1990 Oct;259(4 Pt 1):L320-7. PubMed PMID: 1699434.

 

Mattoli S, Mezzetti M, Riva G, Allegra L, Fasoli A. Specific binding of endothelin on human bronchial smooth muscle cells in culture and secretion of endothelin-like material from bronchial epithelial cells. Am J Respir Cell Mol Biol. 1990 Aug;3(2):145-51. PubMed PMID: 2198895.

 

Mattoli S, Masiero M, Calabrò F, Mezzetti M, Plebani M, Allegra L. Eicosanoid release from human bronchial epithelial cells upon exposure to toluene diisocyanate in vitro. J Cell Physiol. 1990 Feb;142(2):379-85. PubMed PMID: 2154506.

 

Mattoli S, Mezzetti M, Fasoli A, Patalano F, Allegra L. Nedocromil sodium prevents the release of 15-hydroxyeicosatetraenoic acid from human bronchial epithelial cells exposed to toluene diisocyanate in vitro. Int Arch Allergy Appl Immunol. 1990;92(1):16-22. PubMed PMID: 2174022.

 

Gibson PG, Girgis-Gabardo A, Morris MM, Mattoli S, Kay JM, Dolovich J, Denburg J, Hargreave FE. Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax. 1989 Sep;44(9):693-9. PubMed PMID: 2588203; PubMed Central PMCID: PMC462047.

 

Allegra L, Fabbri LM, Picotti G, Mattoli S. Bronchial epithelium and asthma. Eur Respir J Suppl. 1989 Jun;6:460s-468s. Review. PubMed PMID: 2679597.

 

Mattoli S, Fabbri LM, Mapp CE, Allegra L. [Non-allergic factors of bronchial asthma]. Recenti Prog Med. 1989 Feb;80(2):99-106. Review. Italian. PubMed PMID: 2652227.

 

Corbo GM, Foresi A, Morandini S, Valente S, Mattoli S, Ciappi G. Probit analysis applied to the allergen dose-response curve: a method for epidemiologic surveys. J Allergy Clin Immunol. 1988 Jan;81(1):41-7. PubMed PMID: 3339189.

 

Mattoli S, Foresi A, Corbo GM, Valente S, Ciappi G. Effects of two doses of cromolyn on allergen-induced late asthmatic response and increased responsiveness. J Allergy Clin Immunol. 1987 May;79(5):747-54. PubMed PMID: 3106450.

 

Corbo GM, Foresi A, Verga AE, Mattoli S, Polidori G, Ciappi G. Allergy indices based on allergen dose-response curve in a randomly selected sample of schoolchildren. Allergy. 1987 Apr;42(3):230-7. PubMed PMID: 3592147.

 

Mattoli S, Foresi A, Corbo GM, Valente S, Ciappi G. The effect of indomethacin on the refractory period occurring after the inhalation of ultrasonically nebulized distilled water. J Allergy Clin Immunol. 1987 Apr;79(4):678-83. PubMed PMID: 3549843.

 

Mattoli S, Foresi A, Corbo GM, Valente S, Culla G, Toscano L, Bevignani G, Porcarelli MG, Patalano F, Ciappi G. Refractory period to ultrasonic mist of distilled water: relationship to methacholine responsiveness, atopic status, and clinical characteristics. Ann Allergy. 1987 Feb;58(2):134-40. PubMed PMID: 3544970.

 

Foresi A, Mattoli S, Corbo GM, Verga A, Sommaruga A, Ciappi G. Late bronchial response and increase in methacholine hyperresponsiveness after exercise and distilled water challenge in atopic subjects with asthma with dual asthmatic response to allergen inhalation. J Allergy Clin Immunol. 1986 Dec;78(6):1130-9. PubMed PMID: 3537091.

 

Foresi A, Mattoli S, Corbo GM, Polidori G, Ciappi G. Comparison of bronchial responses to ultrasonically nebulized distilled water, exercise, and methacholine in asthma. Chest. 1986 Dec;90(6):822-6. PubMed PMID: 3536341.

 

Mattoli S, Foresi A, Corbo GM, Valente S, Patalano F, Ciappi G. Increase in bronchial responsiveness to methacholine and late asthmatic response after the inhalation of ultrasonically nebulized distilled water. Chest. 1986 Nov;90(5):726-32. PubMed PMID: 3533456.

 

Mattoli S, Foresi A, Corbo GM, Polidori G, Ciappi G. Protective effect of disodium cromoglycate on allergen-induced bronchoconstriction and increased hyperresponsiveness: a double-blind placebo-controlled study. Ann Allergy. 1986 Oct;57(4):295-300. PubMed PMID: 3094411.

 

Mattoli S, Rosati G, Mormile F, Ciappi G. The immediate and short-term effects of corticosteroids on cholinergic hyperreactivity and pulmonary function in subjects with well-controlled asthma. J Allergy Clin Immunol. 1985 Aug;76(2 Pt 1):214-22. PubMed PMID: 4019953.